Effect of surface charge on the brain delivery of nanostructured lipid carriers in situ gels via the nasal route.

@article{Gabal2014EffectOS,
  title={Effect of surface charge on the brain delivery of nanostructured lipid carriers in situ gels via the nasal route.},
  author={Yasmine M Gabal and A. O. Kamel and O. Sammour and A. Elshafeey},
  journal={International journal of pharmaceutics},
  year={2014},
  volume={473 1-2},
  pages={
          442-57
        }
}
The aim of this study was to investigate the influence of the nanocarrier surface charge on brain delivery of a model hydrophilic drug via the nasal route. Anionic and cationic nanostructured lipid carriers (NLCs) were prepared and optimized for their particle size and zeta potential. The optimum particles were incorporated in poloxamer in situ gels and their in vivo behavior was studied in the plasma and brain after administration to rats. Optimum anionic and cationic NLCs of size <200 nm and… Expand
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