Effect of suramin on myotoxicity of some crotalid snake venoms.

  title={Effect of suramin on myotoxicity of some crotalid snake venoms.},
  author={Emerson Z Arruda and Nadia M Silva and Raphael A M Moraes and Paulo Assis Melo},
  journal={Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas},
  volume={35 6},
We investigated the protective effect of suramin, an enzyme inhibitor and an uncoupler of G protein from receptors, on the myotoxic activity in mice of different crotalid snake venoms (A.c. laticinctus, C.v. viridis, C.d. terrificus, B. jararacussu, B. moojeni, B. alternatus, B. jararaca, L. muta). Myotoxicity was evaluated in vivo by injecting im the venoms (0.5 or 1.0 mg/kg) dissolved in physiological saline solution (0.1 ml) and measuring plasma creatine kinase (CK) activity. Two… CONTINUE READING
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