Effect of suramin on human esophageal cancer cells in vitro and in vivo.

@article{Shin1997EffectOS,
  title={Effect of suramin on human esophageal cancer cells in vitro and in vivo.},
  author={R C Shin and Yoshio Naomoto and Yasuaki Kamikawa and Noriaki Tanaka and K. Orita},
  journal={Scandinavian journal of gastroenterology},
  year={1997},
  volume={32 8},
  pages={824-8}
}
BACKGROUND Suramin disrupts several kinds of growth factor receptors. Since human esophageal squamous cell carcinoma expresses abundant epidermal growth factor receptors (EGFR) and proliferates in an autocrine and paracrine manner, it was expected that suramin inhibits tumor growth by disrupting EGFR. METHODS We studied the effect of suramin on the human esophageal squamous cell carcinoma cell line KEsC-II in vitro and in an animal model. RESULTS Cell proliferation was stimulated at a low… CONTINUE READING
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