Effect of supplementation with chromium picolinate on antibody titers to 5-hydroxymethyl uracil

@article{Kato2004EffectOS,
  title={Effect of supplementation with chromium picolinate on antibody titers to 5-hydroxymethyl uracil},
  author={Ikuko Kato and Joseph H. Vogelman and Vladimir Dilman and Jerzy Karkoszka and Krystyna Frenkel and Nancy P. Durr and Norman Orentreich and Paolo G. Toniolo},
  journal={European Journal of Epidemiology},
  year={2004},
  volume={14},
  pages={621-626}
}
Recent in vitro studies have shown that chromium (III) compounds such as chromium picolinate, a popular dietary supplement among people trying to lose weight, produce chromosome damage. We monitored levels of DNA damage in a chromium picolinate supplement trial by measuring antibodies titers to an oxidized DNA base, 5-hydroxymethyl-2'-deoxyuridine (HMdU), by enzyme-linked immunosorbent assays. Ten obese volunteer women completed a 8-week course of 400 μg chromium picolinate per day. In either… 
Chromium picolinate does not produce chromosome damage.
Effects of Chromium Picolinate on Oxidative Damage in Primary Piglet Hepatocytes
TLDR
It is suggested that the appropriate dose (approximately physiological concentration) of chromium picolinate can inhibit lipid peroxidation, and high doses have no significant effects on oxidative damage in piglet hepatocytes, but the existing evidence also imply that exposure to a higher dose appears to be unwarranted.
Evaluation of the potential genotoxicity of chromium picolinate in mammalian cells in vivo and in vitro.
Effects of Chromium Picolinate on Micronucleus Frequency and Morphology of Lymphocytes in Calves
TLDR
This study suggests that supplementation with 200 and 400 µg chromium as chromium picolinate may lead to cytotoxicity and the higher level of supplementation may also have genotoxic effects, however, further studies investigating the mechanism of the action of CrPic are required.
The Safety and Efficacy of High-Dose Chromium Davis
TLDR
There is evidence of hormonal effects of supplemental chromium besides the effect on insulin, and chromium supplementation does result in tissue retention, especially in the kidney, although no pathogenic effect has been demonstrated despite considerable study.
Nutritional supplement chromium picolinate causes sterility and lethal mutations in Drosophila melanogaster
TLDR
X-linked lethal analysis indicates that the nutritional dietary supplement chromium picolinate greatly enhances the rate of appearance of lethal mutations and dominant female sterility.
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