Effect of supplemental dietary glutamine on methotrexate concentrations in tumors.

@article{Klimberg1992EffectOS,
  title={Effect of supplemental dietary glutamine on methotrexate concentrations in tumors.},
  author={V S Klimberg and A. A. Pappas and Emmanuel Nwokedi and J C Jensen and John R. Broadwater and Nicholas P. Lang and Kent C. Westbrook},
  journal={Archives of surgery},
  year={1992},
  volume={127 11},
  pages={
          1317-20
        }
}
This study evaluated the effects of supplemental dietary glutamine (GLN) on methotrexate sodium concentrations in tumors and serum of sarcoma-bearing rats following the initiation of methotrexate. After randomization to a GLN diet (+GLN) or GLN-free diet (-GLN), tumor-bearing rats received 20 mg/kg of methotrexate sodium by intraperitoneal injection. The provision of supplemental GLN in the diet increased methotrexate concentrations in tumor tissues at 24 and 48 hours (38.0 +/- 0.20 nmol/g for… Expand
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TLDR
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TLDR
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