Effect of sulfinpyrazone on homocysteine-induced endothelial injury and arteriosclerosis in baboons.

@article{Harker1983EffectOS,
  title={Effect of sulfinpyrazone on homocysteine-induced endothelial injury and arteriosclerosis in baboons.},
  author={L. Harker and J. Harlan and R. Ross},
  journal={Circulation research},
  year={1983},
  volume={53 6},
  pages={
          731-9
        }
}
The effect of sulfinpyrazone on endothelial injury induced by homocysteine has been studied both in vitro, using cultured human umbilical vein endothelial cells, and in vivo, using a primate model of homocysteine-induced arteriosclerosis. Oral sulfinpyrazone (250 mumol/kg body weight per day in three divided doses) in eight chronically homocystinemic baboons (0.14 +/- 0.04 mM plasma homocystine) decreased the extent of aortic endothelial injury as measured morphometrically by silver staining… Expand
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Hyperhomocysteinemia inhibits post-injury reendothelialization in mice.
Effects of homocysteine on acetylcholine‐ and adenosine‐induced vasodilatation of pancreatic vascular bed in rats
Endothelial dysfunction in a murine model of mild hyperhomocyst(e)inemia.
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References

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EXPERIMENTAL ARTERIOSCLEROSIS
Arteriovenous-shunt thrombosis. Prevention by sulfinpyrazone.
Resistance to arteriosclerosis in pigs with von Willebrand's disease. Spontaneous and high cholesterol diet-induced arteriosclerosis.
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