Effect of subthalamic nucleus or entopeduncular nucleus lesion on levodopa-induced neurochemical changes within the basal ganglia and on levodopa-induced motor alterations in 6-hydroxydopamine-lesioned rats.

@article{Prier2003EffectOS,
  title={Effect of subthalamic nucleus or entopeduncular nucleus lesion on levodopa-induced neurochemical changes within the basal ganglia and on levodopa-induced motor alterations in 6-hydroxydopamine-lesioned rats.},
  author={C{\'e}line P{\'e}rier and Concepci{\'o} Mar{\'i}n and Anna Junque Jim{\'e}nez and Merc{\'e} Bonastre and Eduardo Tolosa and Etienne C. Hirsch},
  journal={Journal of neurochemistry},
  year={2003},
  volume={86 6},
  pages={1328-37}
}
Inactivation of the subthalamic nucleus (STN) or the internal segment of the pallidum (GPi)/entopeduncular nucleus (EP) by deep brain stimulation or lesioning alleviates clinical manifestations of Parkinson's disease (PD) as well as reducing the side-effects of levodopa treatment. However, the effects of STN or entopeduncular nucleus (EP) lesion on levodopa-related motor fluctuations and on neurochemical changes induced by levodopa remain largely unknown. The effects of such lesions on levodopa… CONTINUE READING
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