Effect of substance P on cytokine production by human astrocytic cells and blood mononuclear cells: characterization of novel tachykinin receptor antagonists

@article{Derocq1996EffectOS,
  title={Effect of substance P on cytokine production by human astrocytic cells and blood mononuclear cells: characterization of novel tachykinin receptor antagonists},
  author={J. Derocq and M. S{\'e}gui and C. Blazy and X. Emonds‐Alt and G. Le Fur and J. Breliere and P. Casellas},
  journal={FEBS Letters},
  year={1996},
  volume={399}
}
Substance P (SP) has been reported to induce inflammatory cytokine production in human neuroglial cells and peripheral lymphoid cells as well. In order to evaluate the potency of novel non‐peptide antagonists of the tachykinin receptors as inhibitors of SP‐induced cytokines, we used the astrocytoma cell line U373MG and blood mononuclear cells as models of central and peripheral SP‐target cells, respectively. In the first part of this study, we showed that SR 140333, an NK1 tachykinin receptor… Expand
Substance P-induced priming effects on synovial cells
Substance P-Stimulated Interleukin-8 Expression in Human Colonic Epithelial Cells Involves Protein Kinase Cδ Activation
The role of tachykinins in central nervous system inflammatory responses.
  • I. Marriott
  • Biology, Medicine
  • Frontiers in bioscience : a journal and virtual library
  • 2004
Neuropeptide substance P and the immune response
Role of tachykinins in asthma
...
1
2
3
4
...

References

SHOWING 1-10 OF 33 REFERENCES
Substance P induces tumor necrosis factor in an ex vivo model system.
Interleukin 1 of the central nervous system is produced by ameboid microglia
...
1
2
3
4
...