Effect of subcutaneous injection of a long-acting analogue of somatostatin (SMS 201-995) on plasma thyroid-stimulating hormone in normal human subjects.

@article{Itoh1988EffectOS,
  title={Effect of subcutaneous injection of a long-acting analogue of somatostatin (SMS 201-995) on plasma thyroid-stimulating hormone in normal human subjects.},
  author={Shigeki Itoh and Kiyoshi Tanaka and Mitsuko Kumagae and Fusako Takeda and Kazuaki Morio and Michihiko Kogure and Mitsutoshi Hasegawa and Tadashi Horiuchi and Tatsuya Watabe and Satoshi Miyabe},
  journal={Life sciences},
  year={1988},
  volume={42 26},
  pages={
          2691-9
        }
}
SMS 201-995 (SMS), a synthetic analogue of somatostatin (SRIF) has been shown to be effective in the treatment of the hypersecretion of hormones such as in acromegaly. However, little is known about the effects of SMS on the secretion of thyroid-stimulating hormone (TSH) in normal subjects. In this study, plasma TSH was determined with a highly sensitive immunoradiometric assay, in addition to the concentration of SMS in plasma and urine with a radioimmunoassay, following subcutaneous injection… CONTINUE READING
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