Effect of subchronic lithium treatment on citalopram-induced increases in extracellular concentrations of serotonin in the medial prefrontal cortex.

@article{Muraki2001EffectOS,
  title={Effect of subchronic lithium treatment on citalopram-induced increases in extracellular concentrations of serotonin in the medial prefrontal cortex.},
  author={Ihoko Muraki and Takeshi Inoue and Shinji Hashimoto and Takeshi Izumi and Kiyotaka Ito and Tsukasa Koyama},
  journal={Journal of neurochemistry},
  year={2001},
  volume={76 2},
  pages={490-7}
}
We investigated the effect of citalopram [a selective serotonin (5-HT) reuptake inhibitor; SSRI] and MKC-242 (a selective 5-HT1A agonist), following treatment with subchronic lithium (p.o., 1 week) on extracellular 5-HT concentrations in the medial prefrontal cortex (mPFC). Acute treatment with citalopram (3 and 30 mg/kg) led to significant increases in extracellular 5-HT concentrations. The subchronic lithium group showed significantly higher basal levels of extracellular 5-HT than normal diet… CONTINUE READING

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