Effect of subacute toxic levels of dietary cyclopropenoid fatty acids upon membrane function and fatty acid composition in the rat

@article{Nixon2006EffectOS,
  title={Effect of subacute toxic levels of dietary cyclopropenoid fatty acids upon membrane function and fatty acid composition in the rat},
  author={J. E. Nixon and Thomas A. Eisele and Joseph H. Wales and Russell O. Sinnhuber},
  journal={Lipids},
  year={2006},
  volume={9},
  pages={314-321}
}
The effect of subacute toxicity levels of dietary cyclopropenoid fatty acids upon several physiological parameters was determined in the rat. Diets containing 2% corn oil, 2%Sterculia foetida oil or 2% hydrogenatedSterculia foetida oil were fed.Sterculia foetida oil (50% cyclopropenoid fatty acids) fed rats exhibited retarded growth, elevated organ to body wt ratios, increased saturation of tissue lipid, and abnormal histopathology when compared to corn oil and hydrogenatedSterculia foetida oil… 
Effect of dietary cyclopropene fatty acids on the octadecenoates of individual lipid classes of rat liver and hepatoma
TLDR
The elevated concentrations of oleate indicate that an alternate route of oLEate biosynthesis must exist if the Δ9 desaturation is inhibited by cyclopropene fatty acids as reported previously.
Effect of early postnatal dietary sterculate on the fatty acid composition of rat liver and brain lipids
TLDR
The results suggest that brain nervonic acid may be derived from a precursor other than oleic acid, and that brain desaturase activity was unaffected.
Isolated brain capillary endothelia: Influence of various levels of essential fatty acids on the acyl group composition of glycerophospholipids
TLDR
The relationship between 20∶3n−9 and 20∵4n−6 fatty acids in brain capillary endothelia were markedly increased with a reduction in dietary fat, and low EFA and fat deficient animals showed a tendency to sequester 22∶6n−3.
Metabolism and tissue distribution of label from [9,10-methylene-14C] sterculic acid in the rat
TLDR
The metabolism of14C-sterculic acid, labeled in the methylene carbon of the cyclopropene ring, was investigated in Wistar rats and suggested that rats readily absorb sterculic acid and excrete labeled compounds primarily in the urine.
Differential alteration of Δ9 and Δ6 desaturation of fatty acids in rat brain preparations in vitro
Developing rat brain has the capacity for either Δ9 or Δ6 desaturation of fatty acids. In liver, evidence supports the existence of separate enzymes for each reaction, but it is not known whether in
Effect of various parameters on in vivo Aflatoxin B₁ binding to rainbow trout (Salmo gairdneri) liver DNA
approved: r. JT E. Nix6nj Aflatoxin B-j (AFft,) is a potent liver carcinogen to a number of animal species including rainbow trout (Salmo gairdneri). Microsomal activation is required for the in
Incorporation of label from [9, 10-methylene-14C] sterculic acid in rainbow trout,Salmo gairdneri
The distribution of radioactivity from sterculic acid, labeled on the 9,10-methylene carbon of the cyclopropene ring, was investigated in trout,Salmo gairdneri. Fifty percent of the administered dose
The anticarcinogenic effect of trans-11 18:1 is dependent on its conversion to cis-9, trans-11 CLA by delta9-desaturase in rats.
TLDR
Whether inhibiting Delta9-desaturase with cyclopropenoic fatty acids, supplied by sterculic oil (SO), would reverse the cancer-protective effect observed with a dietary supplement of VA-enriched butter is investigated.
Enantiomeric separation of triacylglycerols containing fatty acids with a ring (cyclofatty acids).
Triacylglycerols (TAGs) containing cyclofatty acids (cycloFAs) from two oilseeds of Sterculia foetida and Hydnocarpus wightiana were analysed using both reversed-phase (RP18) and chiral phase
for the degree of Doctor of Philosophy in Food Science and Technology presented on June 25 , 1984 Title : Alterations in Levels and Synthesis of Proteins in Trout Hepatocytes Due Jo Dietary gyc ] opropenoid Fatty Acids
3 14 Double labeling experiments with [ H]-leucine and [ C]-leucine were performed to compare isolated hepatocyte protein synthesis rates in microsomal and cytosolic fractions from rainbow trout
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TLDR
The synergistic activities of cyclopropenoid fatty acids, epoxyoleic acid, sesame seed oil, and autoxidized salmon oil with aflatoxin B1 were studied in rainbow trout, which promoted early tumor development, increased tumor incidence, and caused a severalfold increase in tumor growth rate over the positive control.
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TLDR
Dietary cyclopropenoid fatty acids (CPFA) suppressed growth rate during the first part of the 200 day feeding trial and caused marked alterations in the cellular morphology of the liver.
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TLDR
Evidence was obtained that the mechanism of inhibition is the irreversible binding of enzyme sulfhydryl groups by the cyclopropene group and it was shown that the inhibition was affected by sterculic acid in vitro with rat liver preparations.
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TLDR
Variations in the nature of the dietary fat resulted in changes in the mixed fatty acid composition of rat erythrocytes, which led to an increased cellular linoleate and arachidonate content whereas diets deficient in linoleates resulted in accumulation of palmitoleic, oleic and eicosatrienoic acids.
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Fatty acid desaturase systems of hen liver and their inhibition by cyclopropene fatty acids
TLDR
Sterculic acid is a more effective inhibitor than either malvalic acid or sterculyl alcohol, probably because these cyclopropene compounds do not block the desaturating site of the enzyme as completely as sterculic acid.
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TLDR
Cyclopropenoid fatty acids fed to female rats in the form of Sterculia foetida oil caused a decrease in mating behavior, fertility, and fetal and newborn viability and pre- and postpartum death of offspring.
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TLDR
Young rainbow trout fed 20 ppb aflatoxin B1 for 1, 5, 10, 20, and 30 days developed 12-month hepatoma incidences and methyl malvalate showed little tumor growth-promoting activity when fed in an identical manner at 50 ppm.
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