Effect of study protocol on the interactions between cimetidine and paracetamol in man

@article{Garba1999EffectOS,
  title={Effect of study protocol on the interactions between cimetidine and paracetamol in man},
  author={Magaji Muhammad Garba and Moji T. B. Odunola and Bestoun H Ahmed},
  journal={European Journal of Drug Metabolism and Pharmacokinetics},
  year={1999},
  volume={24},
  pages={159-162}
}
SummaryThe influence of cimetidine (400 mg) on the salivary pharmacokinetics of oral paracetamol (1 g) was studied in 8 healthy subjects under two protocols — concomitant and delayed administration of cimetidine. There were no significant changes in the salivary pharmacokinetics of paracetamol when the two drugs were concomitantly administered (P > 0.100). Delayed administration of paracetamol 1 h after cimetidine, on the other hand, was associated with significant changes as compared to… CONTINUE READING

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