Effect of structure modification of chondroitin sulfate C on its enantioselectivity to basic drugs in capillary electrophoresis.

@article{Du2002EffectOS,
  title={Effect of structure modification of chondroitin sulfate C on its enantioselectivity to basic drugs in capillary electrophoresis.},
  author={Yingxiang Du and Atsushi Taga and Shigeo Suzuki and Wenying Liu and Susumu Honda},
  journal={Journal of chromatography. A},
  year={2002},
  volume={947 2},
  pages={287-99}
}
The effect of structure modification of chondroitin sulfate C on its enantioselectivity to several representative basic drugs in capillary electrophoresis was investigated. Chemical desulfation showed no remarkable decrease in selectivity, whereas depolymerization with chondroitinase ABC resulted in complete loss of selectivity. Comparison with chondroitin… CONTINUE READING