Effect of stretch on structural integrity and micromechanics of human alveolar epithelial cell monolayers exposed to thrombin.

@article{Trepat2006EffectOS,
  title={Effect of stretch on structural integrity and micromechanics of human alveolar epithelial cell monolayers exposed to thrombin.},
  author={Xavier Trepat and F Puig and N{\'u}ria Gavara and Jeffrey J. Fredberg and Ramon Farr{\'e} and Daniel Navajas},
  journal={American journal of physiology. Lung cellular and molecular physiology},
  year={2006},
  volume={290 6},
  pages={L1104-10}
}
Alveolar epithelial cells in patients with acute lung injury subjected to mechanical ventilation are exposed to increased procoagulant activity and mechanical strain. Thrombin induces epithelial cell stiffening, contraction, and cytoskeletal remodeling, potentially compromising the balance of forces at the alveolar epithelium during cell stretching. This balance can be further compromised by the loss of integrity of cell-cell junctions in the injured epithelium. The aim of this work was to… CONTINUE READING

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