Effect of streptomycin and kanamycin on the course of experimental tularaemia in guinea-pigs

@article{Luka1963EffectOS,
  title={Effect of streptomycin and kanamycin on the course of experimental tularaemia in guinea-pigs},
  author={B. Luk'a{\vs} and M. Hejzlar and J. Libich},
  journal={Folia Microbiologica},
  year={1963},
  volume={8},
  pages={80-88}
}
(1) Guinea-pigs weighing 250–300 g. were treated with daily doses of 10 mg. streptomycin and kanamycin for one and two weeks, starting one, four and seven days after subcutaneous infection with a dose of 10 or 100 MLD of a virulent strain ofPasteurella tularensis; 88–96% were protected from death. The adminis-tration of streptomycin 48 hours before or 24 hours after infection with a sublethal dose had a similar protective effect. (2) No bacteria were cultivated from the lungs or blood after the… CONTINUE READING