Effect of strain and sex on mu opioid receptor-mediated G-protein activation in rat brain.

Abstract

Strain and sex differences in mu opioid-mediated antinociception have been reported in rodents. The present studies evaluated mu opioid receptor-mediated G-protein activation in Lewis and Fischer 344 (F344) male and female rats using agonist-stimulated [35S]GTPgammaS binding. Compared to Lewis rats, F344 rats exhibited a 35% higher level of net DAMGO… (More)

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@article{Selley2003EffectOS, title={Effect of strain and sex on mu opioid receptor-mediated G-protein activation in rat brain.}, author={D. E. Selley and James Taylor Herbert and Drake Morgan and Charles D. Cook and Mitchell J. Picker and L. J. Sim-Selley}, journal={Brain research bulletin}, year={2003}, volume={60 3}, pages={201-8} }