Effect of stimulation rate, sarcomere length and Ca(2+) on force generation by mouse cardiac muscle.

@article{Stuyvers2002EffectOS,
  title={Effect of stimulation rate, sarcomere length and Ca(2+) on force generation by mouse cardiac muscle.},
  author={Bruno D M Y Stuyvers and Andrew D. McCulloch and Jiqing Guo and Henry J. Duff and Hendrick E D J ter Keurs},
  journal={The Journal of physiology},
  year={2002},
  volume={544 Pt 3},
  pages={817-30}
}
The relations between stress, stimulation rate and sarcomere length (SL) were investigated in 24 cardiac trabeculae isolated from right ventricles of mice (CF-1 males, 25-30 g) and superfused with Hepes solution ([Ca(2+)](o) = 1 mM, pH 7.4, 25 degrees C). Stress and SL were measured by a strain gauge transducer and laser diffraction technique, respectively. Stress versus stimulation frequency formed a biphasic relation (25 degrees C, [Ca(2+)](o) = 2 mM) with a minimum at 0.7-1 Hz (~15 mN mm(-2… CONTINUE READING