Effect of sterilization on osteoinduction. Comparison of five methods in demineralized rat bone.

@article{Munting1988EffectOS,
  title={Effect of sterilization on osteoinduction. Comparison of five methods in demineralized rat bone.},
  author={Everard Munting and Jean Francoise Wilmart and A Wijne and Paul Hennebert and C. Delloye},
  journal={Acta orthopaedica Scandinavica},
  year={1988},
  volume={59 1},
  pages={
          34-8
        }
}
The aim of this study was to find a safe, effective sterilization method that does not destroy the bone-inductive capacity of demineralized bone implants. Five sterilizing agents were tested in rats. Implants procured and processed under sterile conditions served as controls. New bone formation was evaluated by determining dry weight, calcium content, and Sr-85 incorporation of the induced ossicles. Glutaraldehyde solution, formaldehyde gas, and ethylene oxide destroyed almost all the bone… CONTINUE READING
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