Effect of stereochemistry, chain length and sequence pattern on antimicrobial properties of short synthetic β-sheet forming peptide amphiphiles.

@article{Ong2014EffectOS,
  title={Effect of stereochemistry, chain length and sequence pattern on antimicrobial properties of short synthetic β-sheet forming peptide amphiphiles.},
  author={Zhan Yuin Ong and Junchi Cheng and Yuan Huang and Kaijin Xu and Zhongkang Ji and Weimin Fan and Yi Yan Yang},
  journal={Biomaterials},
  year={2014},
  volume={35 4},
  pages={
          1315-25
        }
}
In the face of mounting global antibiotics resistance, the identification and development of membrane-active antimicrobial peptides (AMPs) as an alternative class of antimicrobial agent have gained significant attention. The physical perturbation and disruption of microbial membranes by the AMPs have been proposed to be an effective means to overcome conventional mechanisms of drug resistance. Recently, we have reported the design of a series of short synthetic β-sheet folding peptide… CONTINUE READING
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