Effect of steatohepatitis associated with irinotecan or oxaliplatin pretreatment on resectability of hepatic colorectal metastases.


BACKGROUND The objective was to evaluate the effect of preoperative administration of newer chemotherapeutic agents (irinotecan and oxaliplatin) on development of steatohepatitis, which could limit surgical options. STUDY DESIGN Thirty-seven patients were referred for resection of hepatic colorectal metastases. Thirteen patients received no neoadjuvant… (More)