Effect of starvation on human muscle protein metabolism and its response to insulin.

@article{Fryburg1990EffectOS,
  title={Effect of starvation on human muscle protein metabolism and its response to insulin.},
  author={David A. Fryburg and Eugene J. Barrett and R J Louard and Robert A. Gelfand},
  journal={The American journal of physiology},
  year={1990},
  volume={259 4 Pt 1},
  pages={E477-82}
}
Although starvation is known to impair insulin-stimulated glucose disposal, whether it also induces resistance to insulin's antiproteolytic action on muscle is unknown. To assess the effect of fasting on muscle protein turnover in the basal state and in response to insulin, we measured forearm amino acid kinetics, using [3H]phenylalanine (Phe) and [14C]leucine (Leu) infused systemically, in eight healthy subjects after 12 (postabsorptive) and 60 h of fasting. After a 150-min basal period… CONTINUE READING

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