Effect of standing on neurohumoral responses and plasma volume in healthy subjects.

  title={Effect of standing on neurohumoral responses and plasma volume in healthy subjects.},
  author={Giris Jacob and Andrew C. Ertl and J. Richard Shannon and Raffaello Furlan and Rose Marie Robertson and David P. Robertson},
  journal={Journal of applied physiology},
  volume={84 3},
Upright posture leads to rapid pooling of blood in the lower extremities and shifts plasma fluid into surrounding tissues. This results in a decrease in plasma volume (PV) and in hemoconcentration. There has been no integrative evaluation of concomitant neurohumoral and PV shifts with upright posture in normal subjects. We studied 10 healthy subjects after 3 days of stable Na+ and K+ intake. PV was assessed by the Evans blue dye method and by changes in hematocrit. Norepinephrine (NE), NE… CONTINUE READING
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