Effect of standard breakfast on drug absorption and multiple-dose pharmacokinetics of ciprofloxacin.

@article{Ledergerber1985EffectOS,
  title={Effect of standard breakfast on drug absorption and multiple-dose pharmacokinetics of ciprofloxacin.},
  author={Bruno Ledergerber and J. D. Bettex and Beda Joos and Markus Flepp and Ruedi Luethy},
  journal={Antimicrobial agents and chemotherapy},
  year={1985},
  volume={27 3},
  pages={
          350-2
        }
}
Ciprofloxacin was administered to 10 volunteers, who received seven oral doses of 250 mg each at 12-h intervals. Volunteers alternately fasted (F) or received a standard breakfast (B) before the morning dose. Pharmacokinetic parameters were derived from high-pressure liquid chromatography data from samples taken after the first and seventh doses and were analyzed in addition for differences caused by food intake. A significant (P less than 0.05) influence of the standard breakfast on the time… CONTINUE READING
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