Effect of spironolactone on plasma brain natriuretic peptide and left ventricular remodeling in patients with congestive heart failure.

@article{Tsutamoto2001EffectOS,
  title={Effect of spironolactone on plasma brain natriuretic peptide and left ventricular remodeling in patients with congestive heart failure.},
  author={Takayoshi Tsutamoto and Atsuyuki Wada and Kiyoshi Maeda and Naoko Mabuchi and Masaru Hayashi and Takashi Tsutsui and Masato Ohnishi and Masahide Sawaki and Masanori Fujii and Takehiro Matsumoto and Toshiki Matsui and Masahiko Kinoshita},
  journal={Journal of the American College of Cardiology},
  year={2001},
  volume={37 5},
  pages={
          1228-33
        }
}
OBJECTIVES We sought to evaluate the effects of spironolactone on neurohumoral factors and left ventricular remodeling in patients with congestive heart failure (CHF). BACKGROUND Aldosterone (ALD) promotes collagen synthesis and structural remodeling of the heart. Spironolactone, an ALD receptor antagonist, is reported to reduce mortality in patients with CHF, but its influence on left ventricular remodeling has not been clarified. METHODS Thirty-seven patients with mild-to-moderate… CONTINUE READING
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