Effect of spironolactone on cardiovascular complications associated with type-2 diabetes in rats.

Abstract

We have studied the effect spironolactone (20 mg/kg/day) on cardiovascular complications in neonatal model of diabetes in rats, induced by administering 90 mg/kg streptozotocin (STZ), i.p. in 2 day old rats. Diabetes was checked after 12 weeks. At the end of 8 weeks of treatment, various biochemical and cardiac parameters were measured. STZ produced… (More)
DOI: 10.1055/s-0033-1345168

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