Effect of sphingosine and stearylamine on the interaction of phosphatidylserine with calcium. A study using DSC, FT-IR and 45Ca(2+)-binding.

@article{LopezGarcia1995EffectOS,
  title={Effect of sphingosine and stearylamine on the interaction of phosphatidylserine with calcium. A study using DSC, FT-IR and 45Ca(2+)-binding.},
  author={F. Lopez-Garcia and Jos{\'e} Villala{\'i}n and Juan Carmelo Gomez-Fernandez},
  journal={Biochimica et biophysica acta},
  year={1995},
  volume={1236 2},
  pages={
          279-88
        }
}
The lamellar gel to lamellar liquid-crystalline phase transition of dipalmitoylphosphatidylserine (DPPS) multilamellar membranes is abolished by the presence of Ca2+ at DPPS/Ca2+ molar ratios of 2:1 or lower. However, when equimolar sphingosine (SPH) or stearylamine (SA), which are positively charged at the pH studied in this work, were included in DPPS vesicles, the phase transition of DPPS was still observed by differential scanning calorimetry, even in the presence of very high Ca2… Expand
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