Effect of some indole derivatives on xenobiotic metabolism and xenobiotic-induced toxicity in cultured rat liver slices.

@article{Renwick1999EffectOS,
  title={Effect of some indole derivatives on xenobiotic metabolism and xenobiotic-induced toxicity in cultured rat liver slices.},
  author={Anthony B. Renwick and Harsha Mistry and P T Barton and Franck Mallet and R. Jordan Price and Jenny A. Beamand and Brian G Lake},
  journal={Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association},
  year={1999},
  volume={37 6},
  pages={
          609-18
        }
}
  • A. Renwick, H. Mistry, +4 authors B. Lake
  • Published 1 June 1999
  • Chemistry, Medicine
  • Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
In this study the effect of some indole derivatives on xenobiotic metabolizing enzymes and xenobiotic-induced toxicity has been examined in cultured precision-cut liver slices from male Sprague-Dawley rats. While treatment of rat liver slices for 72 hours with 2-200 microM of either indole-3-carbinol (I3C) or indole-3-acetonitrile (3-ICN) had little effect on cytochrome P-450 (CYP)-dependent enzyme activities, enzyme induction was observed after in vivo administration of I3C. The treatment of… 
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    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
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