Effect of somatostatin on ion transport in the rat colon.

@article{Dharmsathaphorn1980EffectOS,
  title={Effect of somatostatin on ion transport in the rat colon.},
  author={Kiertisin Dharmsathaphorn and Lorraine C. Racusen and John W. Dobbins},
  journal={The Journal of clinical investigation},
  year={1980},
  volume={66 4},
  pages={813-20}
}
The effect of somatostatin (SRIF) on ion transport was determined in the rat colon in vitro. SRIF produced a sustained decrease in the short circuit current (Isc) (-0.8 +/- 0.1 mueq/h x cm2) and increased net Cl absorption (0.9 +/- 0.3 mueq/h x cm2). The threshold effect of SRIF on Isc was observed at 6 nM. 10 microM serotonin decreased net Na absorption (-2.6 +/- 0.4 mueq/h x cm2), net Cl absorption (-3.6 +/- 0.5 mueq/h x cm2) and increased Isc (0.7 +/- 0.1 mueq/h x cm2); these changes were… CONTINUE READING

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