Effect of somatostatin analogs on gastric acid secretion in dogs and rats.

@article{Schally1990EffectOS,
  title={Effect of somatostatin analogs on gastric acid secretion in dogs and rats.},
  author={A. Schally and J. Colaluca and D. Paulson and W. Carter and H. Neitzschman and H. Lafaye and R. Cai},
  journal={International journal of peptide and protein research},
  year={1990},
  volume={36 3},
  pages={
          267-74
        }
}
The effects of several superactive analogs of somatostatin on gastric acid response to various exogenous and endogenous stimulants were investigated in conscious dogs and rats with gastric fistulae (GF). The inhibition was compared to that induced by somatostatin-14 (S-S-14) at two dose levels. Several octapeptide analogs of somatostatin including D-Phe-Cys-Tyr-D-Trp-Lys-Val-Cys-Trp-NH2 (RC-160) and D-Phe-Cys-Tyr-D-Trp-Lys-Val-Cys-Thr-NH2 (RC-121), which were superactive in tests on suppression… Expand
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