Effect of soluble and particulate nickel compounds on the formation and repair of stable benzo[a]pyrene DNA adducts in human lung cells.

@article{Schwerdtle2002EffectOS,
  title={Effect of soluble and particulate nickel compounds on the formation and repair of stable benzo[a]pyrene DNA adducts in human lung cells.},
  author={Tanja Schwerdtle and Albrecht Seidel and Andrea Hartwig},
  journal={Carcinogenesis},
  year={2002},
  volume={23 1},
  pages={47-53}
}
Nickel compounds are well-known human carcinogens, but the underlying mechanisms are still not fully understood. Even though only weakly mutagenic, nickel chloride has been shown previously to impair the repair of UV-induced DNA damage as well as oxidative DNA damage. However, the carcinogenic potential depends largely on solubility, with poorly water-soluble nickel subsulfide and nickel oxide being strong carcinogens. Within the present study we investigated the effects of particulate black… CONTINUE READING
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