Effect of sodium zirconium cyclosilicate on potassium lowering for 28 days among outpatients with hyperkalemia: the HARMONIZE randomized clinical trial.

@article{Kosiborod2014EffectOS,
  title={Effect of sodium zirconium cyclosilicate on potassium lowering for 28 days among outpatients with hyperkalemia: the HARMONIZE randomized clinical trial.},
  author={Mikhail Kosiborod and Henrik S. Rasmussen and Philip Lavin and Wajeh Y. Qunibi and Bruce S Spinowitz and David Kenneth Packham and Simon D. Roger and Alex Yang and Edgar Lerma and Bhupinder Singh},
  journal={JAMA},
  year={2014},
  volume={312 21},
  pages={2223-33}
}
IMPORTANCE Hyperkalemia is a common electrolyte abnormality that may be difficult to manage because of a lack of effective therapies. Sodium zirconium cyclosilicate is a nonabsorbed cation exchanger that selectively binds potassium in the intestine. OBJECTIVE To evaluate the efficacy and safety of zirconium cyclosilicate for 28 days in patients with hyperkalemia. DESIGN, SETTING, AND PARTICIPANTS HARMONIZE was a phase 3, multicenter, randomized, double-blind, placebo-controlled trial… CONTINUE READING
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In vitro ion exchange capacity and selectivity of ZS-9, a novel, selective cation trap for the treatment of hyperkalemia

  • A Yang, A Leon, M Nuttall, J Low, H. Rasmussen
  • Am J Kidney Dis
  • 2014

Safety and efficacy of ZS-9, a novel selective cation trap, for treatment of hyperkalemia in CKD patients [abstract

  • S Ash, B Singh, P Lavin, F Stavros, H. Rasmussen
  • J Am Soc Nephrol. 2013;24:2B. Research Original…
  • 2014

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