Effect of sodium tanshinone II A sulfonate on the activity of CYP1A2 in healthy volunteers.

@article{Chen2009EffectOS,
  title={Effect of sodium tanshinone II A sulfonate on the activity of CYP1A2 in healthy volunteers.},
  author={Yao Chen and J-H Tu and Y F He and Wei Zhang and Guo Wang and Z R Tan and Gan Zhou and Lan Fan and H Zhou},
  journal={Xenobiotica; the fate of foreign compounds in biological systems},
  year={2009},
  volume={39 7},
  pages={508-13}
}
Sodium tanshinone IIA sulfonate (STS) is a water-soluble derivative of tanshinone IIA, a famous Chinese medicine which has been used in the treatment of cardiovascular disorders for many years. Using caffeine as a probe drug, this project was designed to investigate the effect of STS on the activity of CYP1A2 in humans. Sixteen unrelated healthy volunteers were recruited for this two-phase, randomized and crossover study. The volunteers received either placebo or 60 mg day(-1) of STS injections… CONTINUE READING

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