Effect of sodium channel blockers on ST segment, QRS duration, and corrected QT interval in patients with Brugada syndrome.

@article{Shimizu2000EffectOS,
  title={Effect of sodium channel blockers on ST segment, QRS duration, and corrected QT interval in patients with Brugada syndrome.},
  author={Wataru Shimizu and Charles Antzelevitch and Kazuhiro Suyama and Takashi Kurita and Atsushi Taguchi and Naohiko Aihara and Hiroshi Takaki and Kenji Sunagawa and Shiro Kamakura},
  journal={Journal of cardiovascular electrophysiology},
  year={2000},
  volume={11 12},
  pages={1320-9}
}
INTRODUCTION Brugada syndrome is characterized by an ST segment elevation in leads V1-V3 and a high incidence of ventricular fibrillation (VF). A mutation in a cardiac Na+ channel gene, SCN5A, has been linked to Brugada syndrome, and sodium channel blockers have been shown to be effective in unmasking the syndrome when concealed. The aim of this study was to examine the effects of Na+ channel blockers on ST segment elevation, QRS, corrected QT (QTc) interval, and ventricular arrhythmias in… CONTINUE READING