Effect of sodium butyrate on synthesis of specific proteins by human breast-carcinoma cells.

Abstract

SODIUM BUTYRATE has been observed to reduce growth rate, alter synthesis of specific proteins and induce biochemical and morphological differentiation, in a variety of cultured tumour-cell lines (Prasad & Sinha, 1976). Its effects on cell lines of human origin include: (1) induction of erythroid differentiation in leukaemia cells (Andersson et al., 1979); (2) induction of neurite formation in neuroblastoma cells (Prasad & Kumar, 1974); (3) stimulation of synthesis of the glycoprotein hormones FSH and hCG, and of their common a-subunit by HeLa cells (derived from cervical carcinoma) (Ghosh & Cox, 1976, 1977; Lieblich et al., 1977); and (4) stimulation of synthesis of osubunit by a bronchial-carcinoma line (Chou et al., 1977). We report here that sodium butyrate has marked effects on protein synthesis in human breast-carcinoma cells. These actions are not limited to induction of differentiation. Production of o-subunit is normally confined to placental tissue and to certain endocrine cells. However, inappropriate synthesis of glycoprotein hormones and their subunits has been noted in a variety of tumour types (Rosen et al., 1975). In order to clarify the actions of butyrate we have studied its effects on the MCF7 human breast-carcinoma line, with regard to synthesis of (a) the milk protein lactal-

DOI: 10.1038/bjc.1980.287

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@article{Grieve1980EffectOS, title={Effect of sodium butyrate on synthesis of specific proteins by human breast-carcinoma cells.}, author={R. J. Grieve and Kent L. Woods and Peggy Mann and Steven Christopher Smith and George D. Wilson and Anthony Howell}, journal={British Journal of Cancer}, year={1980}, volume={42}, pages={616 - 619} }