Effect of sodium bicarbonate supplementation on the renin-angiotensin system in patients with chronic kidney disease and acidosis: a randomized clinical trial

@article{Bove2020EffectOS,
  title={Effect of sodium bicarbonate supplementation on the renin-angiotensin system in patients with chronic kidney disease and acidosis: a randomized clinical trial},
  author={Dominique M. Bov{\'e}e and Lodi C. W. Roksnoer and Cornelis van Kooten and Joris I. Rotmans and Liffert Vogt and Martin H. de Borst and Robert Zietse and A. H. Jan Danser and Ewout J. Hoorn},
  journal={Journal of Nephrology},
  year={2020},
  volume={34},
  pages={1737 - 1745}
}
Acidosis-induced kidney injury is mediated by the intrarenal renin-angiotensin system, for which urinary renin is a potential marker. Therefore, we hypothesized that sodium bicarbonate supplementation reduces urinary renin excretion in patients with chronic kidney disease (CKD) and metabolic acidosis. Patients with CKD stage G4 and plasma bicarbonate 15–24 mmol/l were randomized to receive sodium bicarbonate (3 × 1000 mg/day, ~ 0.5 mEq/kg), sodium chloride (2 × 1,00 mg/day), or no treatment for… 
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