Effect of smokeless tobacco extract on human gingival keratinocyte levels of prostaglandin E2 and interleukin-1.

@article{Johnson1996EffectOS,
  title={Effect of smokeless tobacco extract on human gingival keratinocyte levels of prostaglandin E2 and interleukin-1.},
  author={Georgia K. Johnson and Tim Poore and Jeffrey B Payne and Connie C. Organ},
  journal={Journal of periodontology},
  year={1996},
  volume={67 2},
  pages={
          116-24
        }
}
Gingival recession and white mucosal lesions frequently occur at sites of smokeless tobacco (ST) placement. The etiology of these alterations is presumably related to the irritating effects of tobacco components. The purpose of this study was to examine the effect of an aqueous ST extract (STE) on gingival keratinocyte production of prostaglandin E2 (PGE2) and interleukin-1 (IL-1), mediators involved in periodontal destruction and keratinocyte proliferation. Keratinocyte cultures were… CONTINUE READING
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