Effect of sleep on quazepam kinetics

@article{Hilbert1984EffectOS,
  title={Effect of sleep on quazepam kinetics},
  author={James M. Hilbert and Menger Chung and Gary Maier and Richard Gural and Samson Symchowicz and Nicola Zampaglione},
  journal={Clinical Pharmacology \& Therapeutics},
  year={1984},
  volume={36}
}
The effect of sleep on quazepam kinetics was studied in 12 normal adult men. In a randomized two‐way crossover design, each subject received one 15‐mg quazepam tablet either at night just before sleep or in the morning after a night's sleep. Blood samples were drawn before and at specified times (to 120 hr) after dosing. To assure that blood collection did not interfere with sleep, blood was drawn by an indwelling catheter from a large arm vein. Plasma concentrations of quazepam and its two… 
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