Effect of sinomenine on IL-8, IL-6, IL-2 produced by peripheral blood mononuclear cells

@article{Shenghao2008EffectOS,
  title={Effect of sinomenine on IL-8, IL-6, IL-2 produced by peripheral blood mononuclear cells},
  author={Tu Sheng-hao and Huang Yonghong and Lu Fu-er},
  journal={Journal of Tongji Medical University},
  year={2008},
  volume={19},
  pages={257-259}
}
SummaryThe effect of Sinomenine on IL-8, IL-6, IL-2 and mIL-2R produced by peripheral blood mononuclear cells was investigated by using cell culture, radioimmunoassay and flow cytometry. It was showed that production of IL-8 and mIL-2R was inhibited, but the levels of IL-6 were enhanced by Sinomenine. Our results also demonstrated that Sinomenine did not have any effect on the production of IL-2. The study demonstrated that Sinomenine was able to regulate the production of cytokines. This may… Expand

Figures and Tables from this paper

Effect of sinomenine on collagen-induced arthritis in mice
TLDR
The results suggest that the anti-arthritic effect of SIN may be related to the suppression of both Th1 and Th2 immune responses, and TGF-β may at least in part contribute to the suppressed of Th1 as well as Th2immune responses. Expand
Effects of alkaloid sinomenine on levels of IFN-γ, IL-1β, TNF-α and IL-6 in a rat renal allograft model.
TLDR
The study showed that SIN had immunosupression effects in rat renal allograft models, it also had a synergistic effect in combination with CsA, which provided a new immunosuppressant for clinical application. Expand
Sinomenine promotes differentiation but impedes maturation and co-stimulatory molecule expression of human monocyte-derived dendritic cells.
TLDR
It is shown here that DC differentiation is promoted when monocytes are treated with GM-CSF and IL-4 (IL-4) in the presence of sinomenine (200 microg/ml), as evidenced by the upregulation of CD1a while CD14 was decreased. Expand
Immunoregulatory effects of sinomenine on the T-bet/GATA-3 ratio and Th1/Th2 cytokine balance in the treatment of mesangial proliferative nephritis.
TLDR
Results suggest that a shift toward the Th1 pathway of Th cell activation occurs in MsPGN patients, and that sinomenine has the potential to counter this shift in the Th 1/Th2 balance and thereby produce therapeutic effects. Expand
Sinomenine inhibits the expression of PD‑L1 in the peripheral blood mononuclear cells of mesangial proliferative nephritis patients.
TLDR
A novel mechanism for the therapeutic effects of sinomenine on MsPGN in vivo is suggested, which is observed to have a significant effect in decreasing the PD‑L1 expression in the PBMCs. Expand
Sinomenine attenuates 2, 4, 6-trinitrobenzene sulfonic acid-induced colitis in mice.
TLDR
It is suggested that sinomenine attenuates TNBS-induced colitis in mice and the therapeutic mechanism might be related to the reduction of up-regulated colonic TNF-alpha and IFN-gamma production caused by TNBS. Expand
Analgesic Mechanism of Sinomenine against Chronic Pain
TLDR
Sinomenine's analgesic mechanism is discussed with focus on its role on immune regulation and neuroimmune interaction, and its promising potential for chronic pain management in different clinical settings is discussed. Expand
Sinomenine inhibits activation of rat retinal microglia induced by advanced glycation end products.
TLDR
Sinomenine attenuated ROS production in a dose-dependent fashion and reduced the nuclear translocation of NF-kB p65 in AGEs-activated retinal microglia in culture to determine whether sinomenine could reduce the production of cytokines from the activated microglIA at both gene and protein levels. Expand
Targeting the Monocyte–Macrophage Lineage in Solid Organ Transplantation
TLDR
The effects of currently prescribed immunosuppressive drugs on monocyte/macrophage features and the future challenges are discussed. Expand
Herbal compounds for rheumatoid arthritis: Literatures review and cheminformatics prediction
TLDR
The cheminformatics tools were used to predict their drug‐likeness properties and pharmacokinetic parameters and a total of 90 herbal compounds were analyzed, which were reported to be effective on RA models through anti‐inflammation, chondroprotection, immunoregulation, antiangiogenesis, and antioxidation. Expand
...
1
2
...

References

SHOWING 1-8 OF 8 REFERENCES
Synovium as a source of interleukin 6 in vitro. Contribution to local and systemic manifestations of arthritis.
TLDR
It is demonstrated that synoviocyte-derived IL-6 activity was able to induce hybridoma-plasmacytoma proliferation, and immunoglobulin and acute-phase protein synthesis, which can contribute to important manifestations of inflammatory arthropathies. Expand
Interleukin 6 enhances the production of tissue inhibitor of metalloproteinases (TIMP) but not that of matrix metalloproteinases by human fibroblasts.
TLDR
The results provide the first evidence that IL-6 participates in the catabolism of the extracellular matrix components by modulating the effects of IL-1 on MMPs and TIMP synthesis as well as its direct effects on the synthesis of TIMP by connective tissue cells. Expand
Beneficial effect of monoclonal antibody to interleukin 2 receptor on activated T cells in rheumatoid arthritis.
TLDR
The results suggest that activated T cells are of importance in the pathogenesis of rheumatoid arthritis and the development of humanised monoclonal antibodies targeted against specific T cell sets would allow repeated courses of treatment to be given. Expand
Elevation of interleukin-8 (IL-8) levels in joint fluids of patients with rheumatoid arthritis and the induction by IL-8 of leukocyte infiltration and synovitis in rabbit joints.
TLDR
IL-8 released from monocytes and synovial cells may be an important contributor to leukocyte accumulation and inflammatory events in the joints of RA. Expand
Synovial tissue macrophage as a source of the chemotactic cytokine IL-8.
TLDR
The results suggest that macrophage-derived IL-8 may play an important role in the recruitment of PMN in synovial inflammation associated with RA. Expand
vation of IL - 8 levels in joint fluids of patients with RA and the induction by IL - 8 of leukocyte infiltration and synovitis in rabbit joints
  • phokine Cytokine Res
  • 1991
IL-6 enhances the production of tissue inhibitor of metalloproteinases, but not that of matrix metalloprotinases by human fibroblasts
  • Biochem Biophys Res Commun,
  • 1990
Beneficial effects of monoclonal antibody to IL-2 receptor on activated T-cells in RA
  • Ann Rheum Dis,
  • 1989