Effect of single mutagenesis on the binding pocket of canine estrogen receptor alpha: Structure and binding affinity

@inproceedings{Toniti2016EffectOS,
  title={Effect of single mutagenesis on the binding pocket of canine estrogen receptor alpha: Structure and binding affinity},
  author={W. Toniti and Aekkapot Chamkasem and P. Sangsuriya and P. Puchadapirom},
  year={2016}
}
Hormone-related mammary gland tumors are among the most commonly diagnosed neoplasms in female dogs. Estrogen enacts its biological roles through specific receptors known as estrogen receptors (ER). In human medicine, anti-estrogen therapy has become the gold standard in ER-positive breast tumors’ therapeutic regimen. The binding pocket of the canine estrogen receptor alpha (cERα) ligand binding domain comprises of three key amino acid residues including E354, G522 and L526, which stabilize the… Expand

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