Effect of single and multiple administration of an O 6-benzylguanine/temozolomide combination: an evaluation in a human melanoma xenograft model

@article{Wedge1997EffectOS,
  title={Effect of single and multiple administration of an O 6-benzylguanine/temozolomide combination: an evaluation in a human melanoma xenograft model},
  author={S. Wedge and J. K. Porteous and E. Newlands},
  journal={Cancer Chemotherapy and Pharmacology},
  year={1997},
  volume={40},
  pages={266-272}
}
  • S. Wedge, J. K. Porteous, E. Newlands
  • Published 1997
  • Medicine
  • Cancer Chemotherapy and Pharmacology
  • Abstract The purpose of the present study was to examine the effect of O6-benzylguanine (O6-BG) on the antitumour activity and toxicity of 8-carbamoyl-3-methylimidazo [5, 1-d ] -1,2,3,5-tetrazine-4(3H)-one (temo-zolomide) in a human malignant melanoma xenograft model following single and multiple administration of the combination. O6-BG irreversibly inactivates the DNA-repair protein O6-alkylguanine-DNA alkyltransferase (AGT), which confers resistance to temozolomide. Preadministration of O6-BG… CONTINUE READING
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