Effect of single‐dose injection of vitamin D on immune cytokines in ulcerative colitis patients: a randomized placebo‐controlled trial

  title={Effect of single‐dose injection of vitamin D on immune cytokines in ulcerative colitis patients: a randomized placebo‐controlled trial},
  author={Amrollah Sharifi and Homayoon Vahedi and Saharnaz Nedjat and Hossein Rafiei and Mohammad Javad Hosseinzadeh‐Attar},
  pages={681 - 687}
Ulcerative colitis (UC) is a chronic recurrent inflammation of the colon. It has been proposed that the UC pathogenesis may be related to vitamin D deficiency and/or vitamin D administration in UC patients may have an ameliorating effect on the intestinal inflammation. The aim of this study was to assess the effect of vitamin D on the serum levels of immune cytokines in UC patients. In this double‐blind randomized controlled trial, 90 mild‐to‐moderate UC patients were assigned to get either a… 

Can vitamin D induce remission in patients with inflammatory bowel disease?

It is challenging to define the best doses of VD as a therapeutic adjunct to induce remission in IBD patients, as there are biases in the inclusion of studies, since the route of administration of the VD can vary, as well as the doses and the time of use.

Effects of vitamin D supplementation on blood markers in ulcerative colitis patients: a systematic review and meta-analysis

Compared with placebo control interventions, vitamin D supplementation seemed to be an effective intervention for patients with ulcerative colitis, and Supplementation with a sufficient dose of vitamin D in a short period of time can also improve serum vitamin D levels.

Efficacy of High-Dose Vitamin D Supplementation as an Adjuvant Treatment on Pneumonia: Systematic Review and a Meta-Analysis of Randomized Controlled Studies.

  • Chao YangYifei Lu Guiju Sun
  • Medicine, Biology
    Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition
  • 2020
High-dose VD intervention may have an effect on reducing the incidence rate of repeat episodes of pneumonia by enhancing immune efficacy, although more population studies are needed to support that VD supplementation has therapeutic effects on pneumonia itself.

The Role of Vitamin D in Immune System and Inflammatory Bowel Disease

A broad overview of the role vitamin D in the immune system, especially in the pathogenesis and treatment of IBD, and its possible role in predicting relapse is provided.

The association between vitamin D levels and the clinical severity and inflammation markers in pediatric COVID-19 patients: single-center experience from a pandemic hospital

An association between vitamin D deficiency and clinical severity, in addition to inflammation markers in pediatric CO VID-19 cases is revealed, suggesting an important role of vitamin D in the clinical course of COVID-19 in children and adolescents probably by regulating the systemic inflammatory response.

The Role of Vitamin D in Supporting Health in the COVID-19 Era

A broader view of vitamin D activity is proposed to support a better-integrated approach in supplementation strategies against severe COVID-19, which could be valuable in a near future of living with an infection becoming endemic.

The Role of Vitamin C, Vitamin D, and Selenium in Immune System against COVID-19

The roles of vitamin C, vitamin D, and selenium in the immune system are discussed in relation to COVID-19 in order to maximize the nutritional defense against infections.

Therapeutic effects of vitamin D on acetic acid-induced colitis in rats 1

Calcitriol may be an agent that could be used in acute colitis treatment and there was a significant histological improvement in hyperemia, hemorrhage and necrotic areas in the epithelium compared to the placebo group.



A Randomized Controlled Trial on the Effect of Vitamin D3 on Inflammation and Cathelicidin Gene Expression in Ulcerative Colitis Patients

Low serum levels of 25 (OH)-Vitamin D3, PTH, Calcium, ESR, and hs-CRP and increase in LL37 gene expression support the hypothesis that Vitamin D supplementation may have a beneficial role in UC patients.

Vitamin D Status and Its Relation to Inflammatory Markers in Patients with Mild to Moderate Ulcerative Colitis

In this cross-sectional study 38.9% of the patients with mild to moderate UC were vitamin D deficient or insufficient and vitamin D level was not correlated to ESR and/or hs-CRP, and there were no significant differences in serum 25(OH)D between men and women.

Immunomodulatory Effects of 1,25-Dihydroxyvitamin D3 on TH1/TH2 Cytokines in Inflammatory Bowel Disease: An in Vitro Study

Calcitriol increased, albeit not significantly, IL-10 production in UC compared to CD patients, and the observation that the effect of this modulation was different in CD compared to UC patients provides an important modulatory role of vitamin D in the Th1/Th2 immune response.

A crucial role for the vitamin D receptor in experimental inflammatory bowel diseases.

It is shown that VDR deficiency (knockout, KO) resulted in severe inflammation of the gastrointestinal tract in two different experimental models of IBD, establishing an essential role for VDR signaling in the regulation of inflammation in theintestinal tract.

Vitamin D: new roles and therapeutic potential in inflammatory bowel disease.

This review aims to evaluate the evidence implicating vitamin D deficiency in IBD pathogenesis, to examine vitamin D's anti-inflammatory mechanisms and to explore its therapeutic potential, optimal serum levels and dietary intakes which may support immune function in this disease.

Calcium and 1α,25‐dihydroxyvitamin D3 target the TNF‐α pathway to suppress experimental inflammatory bowel disease

The data support a model where dietary calcium and 1,25D3 treatment directly and indirectly inhibit the TNF‐α pathway and suppress IBD, and suggest that dietary calcium has independent effects on IBD severity and that high calcium and high calcium together result in the maximal suppression of experimental IBD.

Vitamin D and its role in immunology: multiple sclerosis, and inflammatory bowel disease.

  • M. Cantorna
  • Medicine, Biology
    Progress in biophysics and molecular biology
  • 2006

The paradoxical effects of vitamin D on type 1 mediated immunity.

Management of inflammatory bowel disease with vitamin D: beyond bone health.