Effect of single‐dose injection of vitamin D on immune cytokines in ulcerative colitis patients: a randomized placebo‐controlled trial

@article{Sharifi2019EffectOS,
  title={Effect of single‐dose injection of vitamin D on immune cytokines in ulcerative colitis patients: a randomized placebo‐controlled trial},
  author={Amrollah Sharifi and Homayoon Vahedi and Saharnaz Nedjat and Hossein Rafiei and Mohammad Javad Hosseinzadeh‐Attar},
  journal={APMIS},
  year={2019},
  volume={127},
  pages={681 - 687}
}
Ulcerative colitis (UC) is a chronic recurrent inflammation of the colon. It has been proposed that the UC pathogenesis may be related to vitamin D deficiency and/or vitamin D administration in UC patients may have an ameliorating effect on the intestinal inflammation. The aim of this study was to assess the effect of vitamin D on the serum levels of immune cytokines in UC patients. In this double‐blind randomized controlled trial, 90 mild‐to‐moderate UC patients were assigned to get either a… Expand
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There is a lack of well-designed clinical trials exploring the appropriate dose and the influence of gender, age, ethnicity, genetics, microbiome, and metabolic disorders in IBD subtypes, so well- designed therapeutic studies are needed to examine whether enhanced vitamin D will restore functions of VDR and microbiome in inhibiting chronic inflammation. Expand
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