Effect of simvastatin on left ventricular mass in hypercholesterolemic rabbits.

@article{Lee2005EffectOS,
  title={Effect of simvastatin on left ventricular mass in hypercholesterolemic rabbits.},
  author={Tsung-Ming Lee and M Lin and T Z Chou and N K Chang},
  journal={American journal of physiology. Heart and circulatory physiology},
  year={2005},
  volume={288 3},
  pages={H1352-8}
}
Epidemiological studies showed that hypercholesterolemia is associated with higher left ventricular mass. Endothelin signaling is activated in hyperlipidemic animals and may contribute to progressive ventricular hypertrophy. Simvastatin has been shown to inhibit endothelin-1. However, the behavior of simvastatin on ventricular hypertrophy in hyperlipidemic animals is not well understood. In this study, we evaluated the hemodynamic, biochemical, and morphological responses to simvastatin in… CONTINUE READING

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