Effect of simultaneous induction and inhibition of CYP3A by St John's Wort and ritonavir on CYP3A activity.

@article{Hafner2010EffectOS,
  title={Effect of simultaneous induction and inhibition of CYP3A by St John's Wort and ritonavir on CYP3A activity.},
  author={Verena Hafner and Monika J{\"a}ger and A-K Matth{\'e}e and Reinhard Ding and J{\"u}rgen Burhenne and Walter E. Haefeli and Gerd Mikus},
  journal={Clinical pharmacology and therapeutics},
  year={2010},
  volume={87 2},
  pages={191-6}
}
We aimed to assess the effect of coadministration and withdrawal of a potent cytochrome P450 3A (CYP3A) inhibitor (ritonavir) and a potent CYP3A inducer (St John's wort) on CYP3A enzyme activity in an open, fixed-sequence study design. We investigated the pharmacokinetics of midazolam: (i) at baseline, (ii) after a single dose of either St John's wort or ritonavir (each n = 6), (iii) after 14 days of coadministration of ritonavir (300 mg b.i.d.) and St John's wort (300 mg t.i.d.), and (iv) at 2… CONTINUE READING