Effect of simultaneous administration of clofibrate with diethylnitrosamine on hepatic tumorigenesis in the rat.

@article{Mochizuki1983EffectOS,
  title={Effect of simultaneous administration of clofibrate with diethylnitrosamine on hepatic tumorigenesis in the rat.},
  author={Y. Mochizuki and K. Furukawa and N. Sawada},
  journal={Cancer letters},
  year={1983},
  volume={19 1},
  pages={
          99-105
        }
}
Effect of clofibrate administered simultaneously with diethylnitrosamine (DEN) on hepatocarcinogenesis in F344 male rats was investigated. DEN was given in drinking water at a concentration of 40 ppm for 5 weeks. Rats were fed the diet containing clofibrate at concentrations of 0.1% and 0.25% during DEN-treatment. All rats were killed 25 weeks after the beginning of DEN-treatment, and hepatic tumors over 1 mm in diameter were counted. Hepatic tumors in the rats given clofibrate at both… Expand
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