Effect of simulated intestinal fluid on drug permeability estimation across Caco-2 monolayers.

@article{Ingels2004EffectOS,
  title={Effect of simulated intestinal fluid on drug permeability estimation across Caco-2 monolayers.},
  author={Françoise M Ingels and Beno{\^i}t Beck and Marianne Oth and Patrick R Augustijns},
  journal={International journal of pharmaceutics},
  year={2004},
  volume={274 1-2},
  pages={221-32}
}
Presently, the Caco-2 cell culture model is widely used during drug discovery and development as a predictive tool for the oral absorption of drug candidates. For transport experiments in the Caco-2 system, HBSS-like buffered salt solutions are commonly used, although different shortcomings have been associated with the use of these buffers. In this paper, we investigated the effect of using fasted state simulated intestinal fluid (FaSSIF) as potential biorelevant medium for the drug… CONTINUE READING

From This Paper

Topics from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 33 extracted citations

Biopharmaceutical classification of poorly soluble drugs with respect to "enabling formulations".

European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences • 2013
View 8 Excerpts
Highly Influenced

Impact of FaSSIF on the solubility and dissolution-/permeation rate of a poorly water-soluble compound.

European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences • 2012
View 5 Excerpts
Highly Influenced

In vitro disposition profiling of heterocyclic compounds.

International journal of pharmaceutics • 2015
View 3 Excerpts
Highly Influenced

Drug permeability profiling using cell-free permeation tools: Overview and applications.

European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences • 2018

Similar Papers

Loading similar papers…