Effect of silymarin pretreatment on the bioavailability of domperidone in healthy human volunteers

  title={Effect of silymarin pretreatment on the bioavailability of domperidone in healthy human volunteers},
  author={Shravan kumar Yamsani and Madhusudan Rao Yamsani},
  journal={Drug Metabolism and Drug Interactions},
  pages={261 - 267}
Abstract Background: The aim of this study was to investigate the effect of silymarin pretreatment on domperidone oral bioavailability in humans. Methods: The rats were pretreated with silymarin for 7 days. The transport of domperidone across the rat intestine (duodenum, jejunum, ileum, and colon) was studied by using in vitro everted and non-everted sac methods. Samples were collected at preset time points and replaced with buffer. The drug content in the samples was estimated. The first part… Expand
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