Effect of silymarin pretreatment on the bioavailability of domperidone in healthy human volunteers

@article{Yamsani2014EffectOS,
  title={Effect of silymarin pretreatment on the bioavailability of domperidone in healthy human volunteers},
  author={Shravan kumar Yamsani and Madhusudan Rao Yamsani},
  journal={Drug Metabolism and Drug Interactions},
  year={2014},
  volume={29},
  pages={261 - 267}
}
Abstract Background: The aim of this study was to investigate the effect of silymarin pretreatment on domperidone oral bioavailability in humans. Methods: The rats were pretreated with silymarin for 7 days. The transport of domperidone across the rat intestine (duodenum, jejunum, ileum, and colon) was studied by using in vitro everted and non-everted sac methods. Samples were collected at preset time points and replaced with buffer. The drug content in the samples was estimated. The first part… Expand
The effect of diosmin on the pharmacokinetics of fexofenadine in healthy human volunteers
TLDR
It is concluded that intake of DSN or dietary supplements containing DSN may potentially increase the absorption or bioavailability of FEX, a P-gp substrate in humans, and altered pharmacokinetics of Fex might be attributed to DSN-mediated inhibition of P- gp-mediated efflux in humans. Expand
Influence of diosmin on the metabolism and disposition of carbamazepine in healthy subjects
  • S. K. Bedada, P. K. Boga
  • Chemistry, Medicine
  • Xenobiotica; the fate of foreign compounds in biological systems
  • 2017
TLDR
DSN has an inhibiting effect on the metabolism and disposition of CBZ, and the results suggest that the altered CYP3A4 enzyme activity and pharmacokinetics ofCBZ might be attributed to DSN-mediated inhibition of CYP 3A4 enzymes. Expand
Systematic review of pharmacokinetics and potential pharmacokinetic interactions of flavonolignans from silymarin
TLDR
Most human studies showed no silymarin–drug interactions explainable by these suggested interferences, and more interactions were found in animal studies, likely due to the much higher doses administered. Expand
Metabolism, Transport and Drug–Drug Interactions of Silymarin
TLDR
It was concluded that the major efflux transporters of silybin are multidrug resistance-associated protein (MRP2) and breast cancer resistance protein (BCRP) based on results from the transporter-overexpressing cell lines and MRP2-deficient (TR−) rats. Expand
Phytotherapeutics: The Emerging Role of Intestinal and Hepatocellular Transporters in Drug Interactions with Botanical Supplements
TLDR
Some studies on interaction between botanical supplement ingredients and drug transporters such as P-gp and OATPs are described here, suggesting that the interaction betweenBotanical supplements and the drugtransporters is clinically significant. Expand

References

SHOWING 1-10 OF 33 REFERENCES
Study on the influence of silymarin pretreatment on metabolism and disposition of metronidazole.
TLDR
The results indicate that silymarin might induce both intestinal P-glycoprotein and CYP3A4 upon multiple dose administration upon multiple doses administration. Expand
Pharmacokinetic studies with silymarin in human serum and bile.
TLDR
A study in which the absorption of Legalon 35 and Legalon 70 dragees was compared provides an example for bioavailability investigations in the bile, and computation of the value for AUC0-24 and for "mean time" (MT) provided data which enabled bioavailability comparisons to be made. Expand
Analysis of silibinin in rat plasma and bile for hepatobiliary excretion and oral bioavailability application.
TLDR
Intra- and inter-assay precision and accuracy of silibinin fell well within the predefined limits of acceptability (<15%) and the concentration-response relationship from the present method indicated linearity over a concentration range of 0.5-100 microg/mL. Expand
Impact of the changes in P-glycoprotein activity on domperidone pharmacokinetics in rat plasma.
TLDR
GFJ and QD significantly influenced DOM rat plasma concentration during the first two hours after DOM administration indicating that interaction takes place during absorption phase. Expand
On the pharmacokinetics of domperidone in animals and man III. Comparative study on the excretion and metabolism of domperidone in rats, dogs and man
SummaryThe excretion and metabolism of the novel gastrokinetic and antinauseant drug domperidone were studied after oral administration of the14C-labelled compound to rats, dogs and man, and afterExpand
On the pharmacokinetics of domperidone in animals and man IV. The pharmacokinetics of intravenous domperidone and its bioavailability in man following intramuscular, oral and rectal administration
SummaryThe pharmacokinetics and bioavailability of domperidone, a novel gastrokinetic, were studied in healthy male subjects by comparing plasma concentrations and urinary excretion followingExpand
Inhibition of dihydropyridine metabolism in rat and human liver microsomes by flavonoids found in grapefruit juice.
TLDR
The results indicate that the rat may be used for in vivo studies of interactions between flavonoids and dihydropyridines or other drugs that are metabolized by cytochrome P-450 IIIA4. Expand
Inhibitory effects of silibinin on cytochrome P-450 enzymes in human liver microsomes.
TLDR
Silibinin, the main constituent of silymarin, a flavonoid drug from silybum marianum used in liver disease, was tested for inhibition of human cytochrome P-450 enzymes and was a potent competitive inhibitor of dextromethorphan metabolism at the low affinity site. Expand
Silybin and silymarin--new and emerging applications in medicine.
This review critically surveys the literature published mainly within this millennium on the new and emerging applications of silybin (pure, chemically defined substance) and silymarin (flavonoidExpand
Effect of Silybin and its congeners on human liver microsomal cytochrome P450 activities
Silybin and related flavonolignans form a major part of the Silybum marianum extract, silymarin, which has been used to treat liver diseases for hundreds of years. Although regarded as safe, many ofExpand
...
1
2
3
4
...