Effect of silymarin and its polyphenolic fraction on cholesterol absorption in rats.

@article{Sobolov2006EffectOS,
  title={Effect of silymarin and its polyphenolic fraction on cholesterol absorption in rats.},
  author={Lucie Sobolov{\'a} and Nina Skottov{\'a} and Rostislav Ve{\vc}eřa and Karel Urb{\'a}nek},
  journal={Pharmacological research},
  year={2006},
  volume={53 2},
  pages={104-12}
}
This study evaluated the influence of silymarin (SM) and polyphenolic fraction (PF) of silymarin on cholesterol absorption in rats fed on high cholesterol diet (HCD). HCD induced a remarkable increase in hepatic, plasma, VLDL and LDL cholesterol, a decrease in HDL cholesterol and an elevation in triacylglycerol (TAG) levels in plasma, VLDL and in the liver. SM and PF were administered as dietary supplements (1.0%) in HCD for 18 days. Intestinal cholesterol absorption was measured by dual… CONTINUE READING

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