Effect of signal sequence and promoter on the speed of action of a genetically modified Autographa californica nucleopolyhedrovirus expressing the scorpion toxin LqhIT2

@inproceedings{Beek2003EffectOS,
  title={Effect of signal sequence and promoter on the speed of action of a genetically modified Autographa californica nucleopolyhedrovirus expressing the scorpion toxin LqhIT2},
  author={Nikolai A.M. van Beek and A. Xiao Long Lu and Jim Presnail and Dave A. Davis and Cindy Greenamoyer and Kathleen Joraski and Lisa Moore and Michelle D. Pierson and Rafael Herrmann and Lindsey Flexner and James Perry Foster and Aileen Van and James F. H. Wong and Donald L. Jarvis and Gary J. Hollingshaus and Bill F. McCutchen},
  year={2003}
}
Abstract We report on the construction and optimization of recombinant Autographa californica nucleopolyhedrovirus engineered to express the insect-selective toxin IT2 from the scorpion Leiurus quinquestriatus hebraeus . We constructed a series of viruses expressing the synthetic Lqhit2 gene with different signal sequences or controlled by different promoters. The effect of the various viruses on speed of response was assayed in Heliothis virescens larvae. In addition, the performance of the… CONTINUE READING

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