Effect of sigma ligands on the cocaine-induced convulsions in mice.

@article{Skuza1999EffectOS,
  title={Effect of sigma ligands on the cocaine-induced convulsions in mice.},
  author={Grażyna Skuza},
  journal={Polish journal of pharmacology},
  year={1999},
  volume={51 6},
  pages={477-83}
}
It has been hypothesized that some of negative effects exerted by cocaine are mediated via sigma (sigma) receptors. This report demonstrates the effects of selective sigma ligands, panamesine, DTG, rimcazole and SA 4503, on the cocaine-induced convulsions in mice and locomotor hyperactivity in rats. Only panamesine decreased both these effects of cocaine, whereas DTG and rimcazole increased the total time of cocaine-evoked convulsions and locomotor activity. SA 4503 slightly enhanced and… CONTINUE READING

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