Effect of side-stream cigarette smoke on the hepatic cytochrome P450.

@article{Kawamoto1993EffectOS,
  title={Effect of side-stream cigarette smoke on the hepatic cytochrome P450.},
  author={Toshihiro Kawamoto and Masahiro Yoshikawa and Koji Matsuno and Fujio Kayama and Tsunehiro Oyama and Keiichi Arashidani and Yasushi Kodama},
  journal={Archives of environmental contamination and toxicology},
  year={1993},
  volume={25 2},
  pages={255-9}
}
The effect of inhalation of side-stream cigarette smoke on the hepatic microsomal cytochrome P450 was investigated Rats were placed in a chamber of 0.1 m3 in volume, in which cigarettes were burned at the rate of 1, 3, or 5 cigarettes per h, 8 h/day for 5 days. Cytochrome P450 and NADPH-cytochrome c reductase showed no significant changes; however, cytochrome b5 increased significantly. On the other hand, the activity of aryl hydrocarbon hydroxylase (AHH) decreased in the rats treated with a… CONTINUE READING